Adherence and clinical outcomes of hypertensive patients in rural areas after receiving home pharmacy care interventions

Yopi Rikmasari, Ensiwi Munarsih, Hafiza Alfionita

Abstract


Adherence is still a significant problem in the treatment of hypertension, so appropriate interventions are needed to overcome this condition. This study aims to determine the effect of home pharmacy care on medication adherence and clinical outcomes. This research is a pilot study using a quasi-experimental pre- and post-design with control in primary health care facilities in rural areas involving 40 hypertensive patients divided into two each 20 patients in the control and treatment groups. The MGLS questionnaire measured treatment adherence and clinical outcome by assessing blood pressure. Data were analyzed using descriptive statistics, bivariate tests using chi-square, Mann Whitney, paired t-test, and Wilcoxon signed ranks-test. At the beginning and end of the study there was no difference in the level of treatment adherence in the control group (p=0.701) while in the intervention group there was a significant difference (p=0.009). Systolic blood pressure in the control group (p=0.000) and the intervention group (p=0.004) showed a difference, while there was no difference in diastolic blood pressure in the two groups. In addition, there was no difference in achieving blood pressure targets between groups (p=0.522). The findings in this study are that home pharmacy services have the potential to increase medication adherence in rural areas but have not had an impact on reducing pressure and achieving targets.


Full Text:

PDF

References


WHO. World health statistics 2022 (Monitoring health of the SDGs) [Internet]. 2022. 1–131 p. Available from: http://apps.who.int/bookorders.

Kemenkes. Laporan Nasional Riset Kesehatan Dasar. Kementrian Kesehatan Republik Indonesia. Jakarta; 2019.

Gakidou E, Afshin A, Abajobir AA, Abate KH, Abbafati C, Abbas KM, et al. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1345–422.

Joseph T D, Yee GC, Posey LM, Haines ST, Nolin TD, Ellingrod V. Pharmacotherapy a pathophysiologic approach. Eleventh. New York: Mc Graw Hill; 2020.

Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, et al. 2018 practice guidelines for the management of arterial hypertension of the European society of cardiology and the European society of hypertension ESC/ESH task force for the management of arterial hypertension. Vol. 36, European Heart Journal. 2018. 2284–2309 p.

Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691–705.

Abegaz TM, Abdulla Shehab, Gebreyohannes EA, Bhagavathula AS, Elnour AA. Nonadherence to antihipertensive drugs A Systematic review and meta analysis. Medicine (Baltimore). 2017;96(4):e5641.

WHO. Adherence To Long-Term Therapies : Evidence for Action. World Health Organization. 2003.

Pan J, Yu H, Hu B, Li Q. Urban-Rural Difference in Treatment Adherence of Chinese Hypertensive Patients. Patient Prefer Adherence. 2022;16(August):2125–33.

Magnabosco P, Teraoka EC, De Oliveira EM, Felipe EA, Freitas D, Marchi-Alves LM. Comparative analysis of non-adherence to medication treatment for systemic arterial hypertension in urban and rural populations. Rev Lat Am Enfermagem. 2015;23(1):20–7.

Arbuckle C, Tomaszewski D, Aronson BD, Brown L, Schommer J, Morisky D, et al. Evaluating Factors Impacting Medication Adherence Among Rural, Urban, and Suburban Populations. J Rural Heal. 2018;34(4):339–46.

Kemenkes RI. Petunjuk Teknis Standar Pelayanan Kefarmasian di Puskesmas. Kementerian Kesehatan Republik Indonesia. 2019. 1–99 p.

Utaminingrum W, Pranitasari R, Kusuma AM. Pengaruh Home Care Apoteker terhadap Kepatuhan Pasien Hipertensi. J Farm Klin Indones. 2018;6(December 2017):240–6.

Widyastuti S, Yasin NM, Kristina SA, Magister M, Klinik F, Farmasi F, et al. Pengaruh home pharmacy care terhadap pengetahuan , kepatuhan, outcome klinik dan kualitas hidup. Maj Farm. 2019;15(2):105–12.

Utami P, Rahajeng B, Soraya C. Pengaruh edukasi home pharmacy care terhadap kualitas hidup pasien hipertensi di puskesmas. J Farm Sains dan Prakt. 2019;5(1):41–51.

Sugiyono. Metode Penelitian Kuantitatif. Setiyawarni, editor. Bandung: Alfabeta; 2019.

Kristina SA, Putri LR, Riani DA, Ikawati Z, Endarti D. Validity of self-reported measure of medication adherence among diabetic patients in indonesia. Int Res J Pharm. 2019;10(December 2017):144–8.

Sakinah MF, Rejeki DSS, Nurlaela S. Faktor Yang Berhubungan Dengan Kejadian Hipertensi di Pedesaan dan Perkotaan Kabupaten Banyumas (Analisis Data Riskesdas 2018). J Kesmas Indones. 2021;13(1):46–63.

Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, et al. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 2020;75(6):1334–57.

Ernawati I, Fandinata SS, Permatasari SN. Profil Penggunaan Obat Antihipertensi di Puskesmas Surabaya. Lumbung Farm. 2022;3(2):134–8.

Carey RM, Muntner P, Bosworth HB, Whelton PK. Prevention and Control of Hypertension: JACC Health Promotion Series. J Am Coll Cardiol. 2018;72(11):1278–93.

Burnier M, Egan BM. Adherence in Hypertension: A Review of Prevalence, Risk Factors, Impact, and Management. Circ Res. 2019;124(7):1124–40.

Kemenkes RI. Hipertensi. https://p2ptm.kemkes.go.id/dokumen-ptm/leaflet-hipertensi-_-14-x-14-cm. 2022. p. 1.

James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA - J Am Med Assoc. 2014;311(5):507–20.

Artiyaningrum B. Faktor-faktor yang Berhubungan dengan Kejadian Hipertensi tidak Terkendali pada Penderita yang Melakukan Pemeriksaan Rutin. J Perspekt Kesehat Masy. 2016;1(1):12–20.

Newman T V., San-Juan-Rodriguez A, Parekh N, Swart ECS, Klein-Fedyshin M, Shrank WH, et al. Impact of community pharmacist-led interventions in chronic disease management on clinical, utilization, and economic outcomes: An umbrella review. Res Soc Adm Pharm [Internet]. 2020;16(9):1155–65. Available from: https://doi.org/10.1016/j.sapharm.2019.12.016

Reeves L, Robinson K, McClelland T, Adedoyin CA, Broeseker A, Adunlin G. Pharmacist Interventions in the Management of Blood Pressure Control and Adherence to Antihypertensive Medications: A Systematic Review of Randomized Controlled Trials. J Pharm Pract. 2020;20(10):1–13.

Ampofo AG, Khan E, Ibitoye MB. Understanding the role of educational interventions on medication adherence in hypertension: A systematic review and meta-analysis. Hear Lung [Internet]. 2020;49(5):537–47. Available from: https://doi.org/10.1016/j.hrtlng.2020.02.039




DOI: https://doi.org/10.56064/jps.v26i1.947

Refbacks

  • There are currently no refbacks.


   

  

 

 

Creative Commons License

Jurnal Penelitian Sains (JPS) Published by UP2M, Faculty of Mathematic and Natural Science Sriwijaya University is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

 

View My Stats